drug resistance

Modulight Spotlights: LASER-SHARP RESEARCH – September 2024

University of Maryland and Modulight have published together a new research study about the mechanisms of cancer drug resistance. Drug resistance is a leading cause of treatment failure and often has dramatic consequences for survival of cancer patients.

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Screening of photosensitizers-ATP binding cassette (ABC) transporter interactions in vitro

Published in: Cancer Drug Resistance Authors: Shruti Vig1, Payal Srivastava1,#, Idrisa Rahman1,2,#, Renee Jaranson1, Anika Dasgupta1, Robert Perttilä3, Petteri Uusimaa3, Huang-Chiao Huang1  

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Modulight Spotlights: LASER-SHARP RESEARCH – November 2023

Many infectious agents have developed resistance to antibiotics. To combat this problem, Professor Timothy Haystead’s team at Duke University developed a novel light-based antimicrobial strategy that targets non-essential enzyme on the surface of bacteria. Light activation was done using ML7710 with 693 nm laser light to generate reactive oxygen species that successfully sterilized the bacteria.

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Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development

Published in: Cell Chemical Biology Authors: Dave L. Carlson, Mark Kowalewski, Khaldon Bodoor, Matthew R. Redinbo, Neil Spector, Timothy A.J. Haystead Duke University

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