Tag: drug delivery

Modulight Spotlights: LASER-SHARP RESEARCH – July 2026

Laser-sharp Research / drug delivery, liposomes, nanomaterials, nanomedicine, Paclitaxel, photo-oxidation, photothermal therapy, verteporfin / August 6, 2026

Modulight Spotlights: LASER-SHARP RESEARCH – July 2026 The Research Highlight of the Month goes to Eija Ilvesroiha and Professor Timo Laaksonen’s Laboratory of Pharmaceutical Nanotechnology at the University of Helsinki. Their new study investigated the release mechanisms of the chemotherapy drug paclitaxel from light-activated liposomes. These lipid-based carriers have the potential to deliver drugs to [...]

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Photothermal and photo-oxidation mediated release of lipophilic paclitaxel from liposomes: from formulation to in vitro efficacy and molecular dynamics simulations

Scientific papers / 689 nm, 690 nm, 808 nm, drug delivery, ICG, in vitro, liposomes, ML6600, ML8500, MLAKIT, nanomaterials, nanomedicine, Paclitaxel, photo-oxidation, photothermal therapy, University of Helsinki, verteporfin / July 14, 2026

Published in: International Journal of Pharmaceutics Authors: Eija Ilvesroiha, Suvi Heinonen, Riikka Rimmistö, Timo Oksanen, Nikita Durandin, Alex Bunker, Artturi Koivuniemi, Tatu Lajunen, Timo Laaksonen

Photothermal and photo-oxidation mediated release of lipophilic paclitaxel from liposomes: from formulation to in vitro efficacy and molecular dynamics simulations Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – November 2025

Laser-sharp Research / cancer, chemotherapy, drug delivery, glioblastoma, in vitro, laser-sharp research, ML8500, multidrug resistance, photoactivated chemotherapy, Photoimmunotherapy, preclinical, therapy resistance, tumor, University of Maryland, verteporfin / November 19, 2025

Modulight Spotlights: LASER-SHARP RESEARCH – November 2025 We are delighted to highlight new exciting study by Rahman et al. from Dr. Huang-Chiao Huang’s lab at University of Maryland. Multidrug resistance remains a significant barrier to successful chemotherapy outcomes for cancer patients, often caused by active pumping of chemotherapeutics outside of cancer cells. Hence, the team

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Modulight Spotlights: LASER-SHARP RESEARCH – April 2025

Laser-sharp Research / drug delivery, imaging, in vitro, laser-sharp research, light activation, ML6600, nanoparticles, Photodynamic therapy, Photoimmunotherapy, verteporfin / April 30, 2025

Gokalp et al. from University of Massachusetts and Tufts University constructed an innovative liquid metal nanoparticle platform, which has tumor cell targeting and enhanced encapsulation of verteporfin. Charactierization in vitro with the help of ML6600 laser showed effective in vitro phototoxicity.

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Harnessing liposomal nanocellulose hydrogel for NIR-light driven on-demand drug delivery

Scientific papers / 808 nm, drug delivery, drug distribution, hydrogels, in vitro, liposomes, ML8500, nanoparticles, PDT, University of Helsinki / April 4, 2025

Published in: Carbohydrate Polymer Technologies and Applications Authors: Puja Gangurde, Zahra Gounani, Jacopo Zini, Roberta Teixeira Polez, Monika Osterberg, Patrick Lauren, Tatu Lajunen, Timo Laaksonen

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Modulight Spotlights: LASER-SHARP RESEARCH – October 2024

Laser-sharp Research / cancer treatment, drug delivery, hypoxia, laser-sharp research, light activation, liposomes, ML8500, normoxia, University of Helsinki / October 24, 2024

Modulight Spotlights: LASER-SHARP RESEARCH – October 2024 This month, we are highlighting new findings published in RSC Materials Advances by Olga Lem, Roosa Kekki and researchers at Pharmaceutical Nanotechnology research group and Tampere University. The study provides key insights into the role of lipid oxidation in cargo release from light-activated liposomes. These spherical lipid vesicles can

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Development of thermosensitive liposomes with the help of ML8500

Application Note / 808 nm, application note, drug delivery, drug discovery, illumination system, in vitro, indocyanine green, light activation, liposomes, ML6600, ML8500, MLAKIT, University of Helsinki / March 13, 2024

Background The proper delivery and release of therapeutic drugs to a specific site or cell type is one of the main challenges in the treatment of diseases. Liposomes, which are vesicles composed of lipids, serve as carriers for drug delivery thanks to their long circulation time. This results to reduced toxicity in healthy tissues and

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Modulight Spotlights: LASER-SHARP RESEARCH – March 2024

Laser-sharp Research / blood-brain-barrier, brain cancer, drug delivery, glioblastoma, laser-sharp research, ML6600, MLACAL, nanoparticle, University of Maryland / March 7, 2024

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Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery

Scientific papers / 5-ALA, blood-brain-barrier, brain cancer, drug delivery, glioblastoma, MLACAL, Modulight in science, PDT, Photodynamic therapy, photosensitizer, research / March 6, 2024

Published in: Advanced Science Authors: John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang University of Maryland

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