clinical

Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates

Published in: Photochemistry and Photobiology Authors: Hongjing Sun, Michele M. Kim, Yi Hong Ong, Andreea Dimofte, Sunil Singhal, Theresa M. Busch, Keith A. Cengel, Timothy C. Zhu  

Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates Read More »

Modulight Spotlights: LASER-SHARP RESEARCH – December 2024

Timothy C. Zhu et al. at University of Pennsylvania investigated the use of PDT for mesothelioma, an aggressive lung cancer. 24 malignant pleural mesothelioma patients were treated with photodynamic therapy using Photofrin and the ML7710 laser.

Modulight Spotlights: LASER-SHARP RESEARCH – December 2024 Read More »

A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy

Published in: Antioxidants Authors: Hongjing Sun, Yihong Ong, Michele M. Kim, Andreea Dimofte, Sunil Singhal, Keith A. Cengel, Arjun G. Yodh, Timothy C. Zhu  

A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy Read More »

ML7710 for fluorescence imaging: Detection of colorectal polyps in humans using c-Met targeted fluorescent peptide

Motivation for the study Polyps are small growths on the inner lining of the colon or rectum, affecting around 1 in 4 people over the age of 50. Certain types of polyps may eventually become cancerous, and colon cancer prevention relies on colonoscopy using white light to detect and remove the polyps. However, small and

ML7710 for fluorescence imaging: Detection of colorectal polyps in humans using c-Met targeted fluorescent peptide Read More »

Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers

Published in: Frontiers in Immunology Authors: Tone Otterhaug, Sylvia Janetzki, Marij J. P. Welters, Monika Håkerud, Anne Grete Nedberg, Victoria Tudor Edwards, Sanne Boekestijn, Nikki M. Loof, Pål Kristian Selbo, Hans Olivecrona, Sjoerd H. van der Burg, Anders Høgset    

Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers Read More »

Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising dual strategy for local tumor control

Published in: Journal of Neurosurgery Authors: Stephanie Schipmann, Michael Müther, Louise Stögbauer, Sebastian Zimmer, Benjamin Brokinkel, Markus Holling, Oliver Grauer, Eric Suero Molina, Nils Warneke, Walter Stummer    

Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising dual strategy for local tumor control Read More »

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial

Published in: Lancet Oncology Authors: Ahmed A Sultan, Waseem Jerjes, Kristian Berg, Anders Høgset, Charles A Mosse, Rifat Hamoudi, Zaid Hamdoon, Celia Simeon, Dawn Carnell, Martin Forster, Colin Hopper    

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial Read More »

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