Tag: clinical

Modulight Spotlights: LASER-SHARP RESEARCH – December 2024

Laser-sharp Research / clinical, laser-sharp research, mesothelioma, ML7710, personalized medicine, pulmonology, real-time monitoring

Timothy C. Zhu et al. at University of Pennsylvania investigated the use of PDT for mesothelioma, an aggressive lung cancer. 24 malignant pleural mesothelioma patients were treated with photodynamic therapy using Photofrin and the ML7710 laser.

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Modulight Spotlights: LASER-SHARP RESEARCH – April 2024

Laser-sharp Research / abscess, antibiotic resistance, bacterial infection, clinical, clinical trial, clinical trials, illumination, infection, laser-sharp research, methylene blue, ML7710, ML7710-PDT, PDT, Photodynamic therapy, radiology, University of Rochester

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ML7710 for fluorescence imaging: Detection of colorectal polyps in humans using c-Met targeted fluorescent peptide

Application Note / cancer, clinical, colonoscopy, colorectal cancer, customer, diagnostics, fluorescence detection, fluorescence imaging, GE Healthcare, imaging, Leiden University Medical Center, ML7710, oncology, polyps, targeted agents

Motivation for the study Polyps are small growths on the inner lining of the colon or rectum, affecting around 1 in 4 people over the age of 50. Certain types of polyps may eventually become cancerous, and colon cancer prevention relies on colonoscopy using white light to detect and remove the polyps. However, small and

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Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers

Scientific papers / clinical, drug delivery, fimaporfin, ML7710, Photochemical Internalization, T-cell response

Published in: Frontiers in Immunology Authors: Tone Otterhaug, Sylvia Janetzki, Marij J. P. Welters, Monika Håkerud, Anne Grete Nedberg, Victoria Tudor Edwards, Sanne Boekestijn, Nikki M. Loof, Pål Kristian Selbo, Hans Olivecrona, Sjoerd H. van der Burg, Anders Høgset

Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers Read More »

Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising dual strategy for local tumor control

Scientific papers / 5-ALA, clinical, compassionate care, FGR, Fluorescence-guided resection, glioblastoma, ML7710, PDT, PPIX

Published in: Journal of Neurosurgery Authors: Stephanie Schipmann, Michael Müther, Louise Stögbauer, Sebastian Zimmer, Benjamin Brokinkel, Markus Holling, Oliver Grauer, Eric Suero Molina, Nils Warneke, Walter Stummer

Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising dual strategy for local tumor control Read More »

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial

Scientific papers / 652 nm, clinical, H&N cancer, head & neck cancer, ML7710, Phase 1, Photochemical internalisation, TPCS2a

Published in: Lancet Oncology Authors: Ahmed A Sultan, Waseem Jerjes, Kristian Berg, Anders Høgset, Charles A Mosse, Rifat Hamoudi, Zaid Hamdoon, Celia Simeon, Dawn Carnell, Martin Forster, Colin Hopper

Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial Read More »

Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met

Scientific papers / 635 nm, clinical, colonoscopy, colorectal cancer, colorectal polyps, Cy5, EMI-137, fluorescence, GE-137, in vivo, ML7710

Published in: Nature Medicine Authors: Jacobus Burggraaf, Ingrid M C Kamerling, Paul B Gordon, Lenneke Schrier, Marieke L de Kam, Andrea J Kales, Ragnar Bendiksen, Bård Indrevoll, Roger M Bjerke, Siver A Moestue, Siavash Yazdanfar, Alexandra M J Langers, Marit Swaerd-Nordmo, Geir Torheim, Madhuri V Warren, Hans Morreau, Philip W Voorneveld, Tessa Buckle, Fijs W

Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met Read More »