Tag: brain cancer

Modulight Spotlights: LASER-SHARP RESEARCH – March 2024

Laser-sharp Research / blood-brain-barrier, brain cancer, drug delivery, glioblastoma, laser-sharp research, ML6600, MLACAL, nanoparticle, University of Maryland

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Carrier-Free, Amorphous Verteporfin Nanodrug for Enhanced Photodynamic Cancer Therapy and Brain Drug Delivery

Scientific papers / 5-ALA, blood-brain-barrier, brain cancer, drug delivery, glioblastoma, MLACAL, Modulight in science, PDT, Photodynamic therapy, photosensitizer, research

Published in: Advanced Science Authors: John A. Quinlan, Collin T. Inglut, Payal Srivastava, Idrisa Rahman, Jillian Stabile, Brandon Gaitan, Carla Arnau Del Valle, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Baktiar Karim, Nina Connolly, Robert W. Robey, Graeme F. Woodworth, Michael M. Gottesman, Huang-Chiao Huang University of Maryland

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Light penetration depth in brain with different photosensitizers

Application Note / 5-ALA, 635 nm, 689 nm, BPD, brain cancer, glioblastoma, ML6600, PDT, Photoimmunotherapy, PIT, PPIX, University of Maryland, verteporfin

Motivation for the study Glioblastoma is the most aggressive and lethal brain cancer with an average prognosis of 15 months. Fluorescence-guided surgery (FGS) for glioblastoma was FDA-approved in 2017, while photodynamic therapy (PDT) remains an active area of clinical investigation with very promising results so far. The aim of PDT is to eradicate the

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Photothermal therapy with platinum nanoparticles

Application Note / 808nm, brain cancer, ex vivo, in vitro, ML6600, MLAKIT, Niels Bohr Institute, NIR, ovarian cancer, photothermal therapy, platinum nanoparticles, preclinical, University of Copenhagen

Photothermal therapy efficiency Human ovarian cancer cells were plated on Petri dishes and incubated with platinum nanoparticles of varying sizes between 30 and 70 nm. After 24-hour incubation, irradiation was performed using a Modulight ML6600 laser at 808 nm together with an illumination kit (MLAKIT) tailored for Petri dish illumination. A small area of the dish

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ML7710 for glioblastoma treatment

Application Note / 5-ALA, brain cancer, fluorescence-guided surgery, glioblastoma, ML7710, PDT, Photodynamic therapy, PPIX, reactive oxygen species, UKM, University Hospital Münster

Background Professor Stummer on glioblastoma surgeries and iPDT: Treatment protocol 20 patients were treated. 5-ALA (Gliolan) was administered at a dosage of 20 mg/kg body weight 4 hours before anesthesia. Craniotomy was performed using FGR, with aim of maximal safe resection of the fluorescent tumor. Once there was no visible fluorescence or only

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