Tag Archives: antimicrobialtherapy

Modulight Spotlights: LASER-SHARP RESEARCH – October 2023

 Modulight Spotlights: LASER-SHARP RESEARCH – October 2023 ​Antimicrobial resistance is an increasing healthcare problem, with new effective treatment strategies urgently needed. Professor Mitsunaga and team at The Jikei University Medical School, Japan, describe a promising treatment called photoimmuno-antimicrobial strategy (PIAS) in a new Nature publication. Detailed instructions how to design and implement the treatment are given, with Modulight’s ML7710 and ML6600 series lasers validated for drug activation in the protocol. This treatment enables targeted elimination of different microbes, regardless of the species or drug resistance Continue reading →

Pharmaceutical nanotechnology applied to phthalocyanines for the promotion of antimicrobial photodynamic therapy: A literature review

Published in: Photodiagnosis and Photodynamic Therapy Authors: Luciana Betzler de Oliveira de Siqueira, Ana Paula dos Santos Matos, Marcio Robert Mattos da Silva, Suvene Rocha Pinto, Ralph Santos-Oliveira, Eduardo Ricci-Júnior  Published in: Photodiagnosis and Photodynamic Therapy Authors: Luciana Betzler de Oliveira de Siqueira, Ana Paula dos Santos Matos, Marcio Robert Mattos da Silva, Suvene Rocha Pinto, Ralph Santos-Oliveira, Eduardo Ricci-Júnior   Phthalocyanines are photosensitizers activated by light at a specific wavelength in the presence of oxygen and act through the production of Reactive Oxygen Species, which simultaneously attack several biomolecular targets in the pathogen agent and, therefore, have multiple and variable action sites. This nonspecific action site bypasses conventional resistance mechanisms. Antimicrobial Photodynamic Therapy (aPDT) is Continue reading →