Published in: Results in Chemistry
Authors: Tanvi A. Desphande, Andi Zeng, Michelle Young, Terrence Nicholson, Karen Luo, Sudip Timilsina, Bryan Q. Spring, Peter Müller, Neha Kulkarni, Swati Betharia, Ronny Priefer
A novel class of platinum containing anticancer agents, specifically aza‑platinum-dipyrromethenes (aza-PLADIPYs), was synthesized and assessed. It was hypothesized that agents would work as dual-acting anticancer agents that could able produce both DNA crosslinking chemotoxicity as well as phototoxicity. Agents were activated with different light sources, either white light, 630 nm LED or 690 nm laser (ML6000- series laser) and also compared to Photofrin. Compounds did not produce any additional phototoxicity with light activation. Compound 4 exhibited strongest cytotoxicity (78%) which was higher than cisplatin (54%) but lower than Photofrin with light activation (99%).
