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Photothermal and photo-oxidation mediated release of lipophilic paclitaxel from liposomes: from formulation to in vitro efficacy and molecular dynamics simulations

Published in: International Journal of Pharmaceutics

Authors: Eija Ilvesroiha, Suvi Heinonen, Riikka Rimmistö, Timo Oksanen, Nikita Durandin, Alex Bunker, Artturi Koivuniemi, Tatu Lajunen, Timo Laaksonen

The study investigated photothermal (ICG) and photo-oxidative (verteporfin) activation of liposomes for anticancer drug delivery. Surprisingly, photoactivation of paclitaxel-loaded liposomes did not release paclitaxel with neither photothermal nor photo-oxidative release even at highest tested light doses. ML8500 was used for photo-oxidative release (689 nm) while ML6600 with MLAKIT for photothermal release (808 nm). Molecular dynamic simulations showed that paclitaxel remains trapped within oxidized lipids after liposomal disruption. While results show release of lipophilic drugs might not be successful, verteporfin-containing liposomes successfully released hydrophilic calcein.

 

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Modulight products used:

ML6600 – High-power laser system with multi-wavelength support

 

Illumination kit for in vitro and in vivo research (MLAKIT)

ML8500 automatic illumination system for well plates sequential illumination
ML8500 – Automatic Biomedical Illumination System
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