Published in: PLoS One
Authors: Bruce van Dijk, Sabrina Oliveira, J. Fred F. Hooning van Duyvenbode, F. Ruben H. A. Nurmohamed, Vida Mashayekhi, Irati Beltrán Hernández, Jos van Strijp, Lisanne de Vor, Piet C. Aerts, H. Charles Vogely, Harrie Weinans, Bart C. H. van der Wal
Photoimmuno-antimicrobial therapy (PIAT) was develop to treat implant infections that cause high morbidity and mortality worldwide. Antibody targeting Wall Teichoic Acid surface components of both S. aureus and its biofilm was conjugated to a photosensitizer IRDye700DX and used as photoimmunotherapy in vitro and in vivo in mice with a subcutaneous implant precolonized with biofilm of S. aureus. ML7700 was used for PIAT to eradicate S. aureus implant infection in vitro and in vivo.
