Published in: Journal of Drug Delivery Science and Technology
Authors: Jose Quílez−Alburquerque, Fernanda Viana Cabral, Yanfang Feng, Tayyaba Hasan
Photoactivatable liposomes were investigated for their potential to deliver antibiotics (minocycline) as antimicrobial therapy against antibiotic resistant bacterial strains. The liposomal delivery platform co-encapsulated minocycline with light-sensitive compound benzoporphyrin derivative (BPD) to enable simultaneous intracellular delivery at synergistic ratios. Synergistic antibacterial effect was shown against when irradiated with sub-lethal light dose using ML6600 laser. This complimentary therapeutic strategy can help with shortage of new antibiotics and growing antibiotic resistance.
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