Published in: Translational Oncology
Authors: Motofumi Suzuki, Hisataka Kobayashi, Hirofumi Hanaoka
Osteosarcoma is the most common bone tumor, and it possesses high metastatic propensity. In this study, the potential of near-infrared photoimmunotherapy was studied for ostesarcoma in vitro and in vivo. ML7710 was used as a light source for PIT. NIR-PIT significantly suppressed tumor growth with no adverse effects in tumor-bearing mice. This study revealed that NIR-PIT targeting EGFR has therapeutic effects and induces immunogenic cell death in osteosarcoma.
