Published in: Cancer Science
Authors: Fuyuki F. Inagaki, Makoto Kano, Aki Furusawa, Takuya Kato, Ryuhei Okada, Hiroshi Fukushima, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi
In this study, the efficacy of PD-L1-targeted NIR-PIT (photoimmunotherapy) with ML7710 was assessed in immune-competent tumor mouse models. PIT showed a significant therapeutic effect on the tumor models with high PD-L1 expression. Furthermore, it induced an abscopal effect on distant tumors and long-term immunological memory. Combination with interferon-gamma improved the treatment efficacy by increasing PD-L1 expression leading to more efficient cell killing, leading to complete responses even in cold tumors.
