Published in: Cancer Science
Authors: Hiroshi Yamamoto, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Motofumi Suzuki, Makoto Kano, Miyu Kano, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi
The study evaluated the potential of Vitamin C in reducing pain and edema associated with photoimmunotherapy, which can lead to significant complications such as airway obstruction. Edema and pain are likely mediated by reactive species formed during the illumination, which could be neutralized by vitamin C, a potent reducing agent and proton donor. Vitamin C demonstrated concentration-dependent inhibition of edema after NIR-PIT without compromising the efficacy. Furthermore, it did not impede the anticancer immune activation elicited by NIR-PIT and resulted in similar survival. ML7710 laser was used for photoimmunotherapy activation in vitro and in vivo.
