Published in: npj Acoustics
Authors: Andrew Langley, Allison Sweeney, Ronak T. Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi
Heterogenous oxygen consumption during PDT is correlated with treatment response. Monitoring blood oxygen saturation also during PDT using ultrasound-guided photoacoustic imaging was shown to be a useful marker for long-term efficacy of PDT and inform dose design for treatment decisions. ML6600 was used for PDT together with BPD photosensitizer in vivo through a custom-designed four-way source-split optical fibers. All four fiber holders were angled at 10º from the elliptical plane, which allowed uniform illumination of the entire tumor.
