Published in: Carbohydrate Polymer Technologies and Applications
Authors: Puja Gangurde, Zahra Gounani, Jacopo Zini, Roberta Teixeira Polez, Monika Osterberg, Patrick Lauren, Tatu Lajunen, Timo Laaksonen
The study investigated integration of stimuli-responsive liposomes with cellulose nanofiber hydrogel to tackle challenges with biodegradation and toxicity, which often hinder application of nanoparticles. Liposomes act as drug reservoirs, provide control over drug distribution, and prevent unwanted cargo leakage, while cellulose nanofiber hydrogel improves biocompatibility, sustained drug release, and protects from immunogenicity and accumulation to liver and spleen, enabling truly localized and targeted release through implantable drug delivery system. ML8500 was used to study calcein release from liposome-loaded hydrogels over time to compare release with light (ML8500) to heat (ThermoMixer). Up to 50% of release was observed at low light dose (20 J/cm2), while 80% release was shown with higher light dose (80 J/cm2), demonstrating sensitivity of the system. Light produced identical release-% than heating for 10 min but in a shorter time (80s), indicating hydrogels as rate-limiting step in the release.
