Published in: Langmuir
Authors: Sumiao Pang, Rebecca J. Johnson, Nikhil Pandey, Anshika Kapur, Pavlos Anastasiadis, Pranjali Kanvinde, Emylee McFarland, Jeffrey A. Winkles, Graeme F. Woodworth, Anthony J. Kim, Huang Chiao Huang
Gold nanorods were studied as an improved, safer targeted method for laser interstitial thermal therapy (LITT) of gliomas. Nanorods were surface-functionalized with Fn14 antibody and polyethylene glycol to achieve better selectivity and low adhesivity to extracellular matrix. Heating receptor-targeted nanorods with red light (ML6600) raised temperature of tissue-mimicking phantoms significantly and rapidly and enhanced photothermal killing in GBM cells compared to non-targeted gold nanorods.
