Published in: Chest Pulmonary
Authors: Jason Beattie, Mario Ghosn, Kwanghee Kim, Raymond Parrish, Jie Chen, Stephen B. Solomon, Sebastien Monette, Christopher Cheleuitte-Nieves, Reza Bergemann, Mohit Chawla, Bryan C. Husta, Or Kalchiem-Dekel, Yaniv Cohen, Dina Preise, Zachary Sacks, Avigdor Scherz, Lonny Yarmus, Jonathan A. Coleman, Robert P. Lee
Feasibility and pathologic outcomes of vascular targeted photodynamic therapy (VTP) for peripheral lung in healthy pigs was reported. Broncoscopic VTP could offer benefits to treatment of lung tumors by avoiding prolonged photosensitivity and allowing infusion and illumination within the same procedure due to short drug-light interval of padeliporfin. Thirty ablations were performed with ML7710 and diffuser fiber across 15 animals, with varying light doses. Results demonstrated initial feasibility and reasonable safety, resulting in ablation zones on chest CT scan with coagulative necrosis and acute inflammatory zones.
