Published in: Nature Reviews Bioengineering
Authors:
- Girgis Obaid, University of Texas at Dallas
- Jonathan P. Celli, University of Massachusetts Boston
- Mans Broekgaarden, Grenoble Alpes University
- Anne-Laure Bulin, Grenoble Alpes University
- Petteri Uusimaa, Modulight Corporation
- Brian Pogue, University of Wisconsin School of Medicine
- Tayyaba Hasan, Harvard Medical School
- Huang-Chiao Huang, University of Maryland
The review article explores the advanced applications of PDT, a photochemistry-based treatment approach that utilizes light-activated photosensitizers to generate reactive oxygen species for localized cellular cytotoxicity. The paper discusses the underlying mechanisms of PDT and photodynamic priming (PDP), their roles in cancer treatment, and the engineering of photosensitizers for enhanced efficacy and specificity.
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