Published in: Frontiers in Oncology
Authors: Sadna Budhu, Kwanghee Kim, Wesley Yip, Stephen La Rosa, Sylvia Jebiwott, Liqun Cai, Aliya Holland, Jasmine Thomas, Dina Preise, Alex Somma, Benjamin Gordon, Avigdor Scherz, Jedd D. Wolchok, Joseph Erinjeri, Taha Merghoub, Jonathan A. Coleman
Three forms of localized tumor destruction (radiation therapy, vascular targeted PDT and cryoablation) were compared for their efficacy in evoking local and systemic immune responses. This has potential to improve effectiveness of immunotherapy in non-responding patients (cold tumors) by attracting T cells to the tumor and inducing abscopal effects. ML7710 was used for vascular targeted PDT for activating Tookad. All three methods were shown to significantly delay tumor growth and extend survival in mouse breast cancer model, with radiotherapy inducing different response than other studied therapies.
