Published in: International Journal of Cancer
Authors: Hiroshi Fukushima, Seiichiro Takao, Aki Furusawa, Motofumi Suzuki, Youfeng Yang, Christopher J. Ricketts, Makoto Kano, Shuhei Okuyama, Hiroshi Yamamoto, Miyu Kano, Mark W. Ball, Peter L. Choyke, W. Marston Linehan, Hisataka Kobayashi
Carbonic anhydrase-9 (CA9) is highly expressed in clear cell renal cell carcinoma but not in normal kidney tissues. CA9-targeted photoimmunotherapy was developed by conjugating IR700 to CA9-antibody and using ML7710 for drug activation. In vitro, it showed cell membrane damage and cell killing across multiple renal cancer cell lines. In vivo, PIT prolonged survival and 70-80% of mice achieved a complete remission after a single PIT session.
