Breaking the selectivity‑uptake trade‑off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi‑tier cancer targeting

Published in: Journal of Nanobiotechnology

Authors: Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali , Tayyaba Hasan, Huang‑Chiao Huang


The ML6600 laser was used to test the PDT efficacy of a novel photoimmunoconjugate-nanoliposome (PIC-Nal) comprising of EGFR-targeted Cetuximab, BPD photosensitizer and irinotecan chemoterapy inside a liposome. Different cancer cell lines were used and cell viability was determined after PDT.


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