Published in: Antioxidants
Authors: Hongjing Sun, Yihong Ong, Michele M. Kim, Andreea Dimofte, Sunil Singhal, Keith A. Cengel, Arjun G. Yodh, Timothy C. Zhu
Accurate dosimetry, accounting for all three PDT components (light, tissue oxygen, photosensitizer), is crucial for predicting and optimizing PDT outcomes. This study determined tissue oxygenation from non-invasive diffuse correlation spectroscopy (DCS) measurement of tumor blood flow. 24 mesothelioma patients were enrolled into the study and treated with PDT using ML7710. Explicit dosimetry of light fluence, Photofrin concentration, and tissue oxygenation concentrations were integrated into the mathematical model to calculate [ROS] across multiple sites inside the pleural cavity and among different patients, and significant heterogeneity was observed.
