Published in: Photochemistry and Photobiology
Authors: Sumeyra Gokalp, Marvin Xavierselvan, Mohammad Forhad Khan, Ronak Shethia, Sima Khani, Ryan H. Riddell, Anna V. Krasnoslobodtseva, Srivalleesha Mallidi, Michelle Foster
Clinical application is constrained by poor solubility, rapid clearance, and inadequate tumor accumulation of photosensitizers. The study presents an innovative liquid metal nanoparticle (LMNP) platform, composed of gallium–indium eutectic alloy (EGaIn), engineered to address these drug delivery challenges in PDT. Extensive in vitro characterization of nanoparticle was conducted, including photostability with ML600 irradiation, in vitro phototoxicity, drug release, and cellular uptake, showing promising characteristics. Additionally, the integration of drug delivery, PDT, and imaging capabilities within a single platform presents opportunities for more effective and personalized cancer therapies.
