Modulight Spotlights: LASER-SHARP RESEARCH – September 2026
Could locally generated bioluminescence be used to activate photoimmunotherapy, potentially enabling treatment of disseminated metastatic disease? To address this question, research teams at Northeastern University and Cornell University genetically engineered immune cells to express luciferase, making cells to emit blue or red light and activate verteporfin in 3D ovarian cancer spheroid models. It was shown that bioluminescence-based activation remained below the threshold required for effective cytotoxicity, while conventional light activation using the ML6500 laser system produced a clear light dose-dependent increase in therapeutic response.
Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!
#Laser-Sharp Research #photodynamicpriming #photodynamictherapy #luciferase #bioluminescence
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About Modulight’s LASER-SHARP RESEARCH concept:
Laser-Sharp Research is a concept where our scientific board highlights cutting-edge scientific research articles from our customers. Important selection criteria are that Modulight and laser product are mentioned in the publication, the impact and relevance of the results, clinical translatability, as well as scientific quality of the journal. The nominated research groups will be rewarded to encourage the great work done.
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