The development of chemoresistance presents a major challenge in treating peritoneal metastasis, which often occurs in advanced ovarian cancer. To tackle this, Kaitlyn Moore and teams at University of Maryland and National Cancer Institute evaluated photoimmunotherapy as a solution to inhibit a drug efflux pump on cancer cells that is often responsible for removing chemotherapeutics outside of cancer cells and causing decreased efficacy. Photoimmunoconjugates were developed and their ROS-generation was tested using the ML8500 in vitro system, after which low-dose photoimmunotherapy was given with the ML7710 medical laser. Results were impressive: drug retention was enhanced within the peritoneal metastases, showing also good safety profile.

Modulight is very happy to be supporting this research. We would like to deliver our warmest congratulations to the research team!

#Laser-Sharp Research  #chemoresistance  #ovariancancer  #peritonealcarcionoma #photoimmunotherapy #targetedtherapies

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About Modulight’s LASER-SHARP RESEARCH concept:

Laser-Sharp Research is a concept where our scientific board highlights cutting-edge scientific research articles from our customers. Important selection criteria are that Modulight and laser product are mentioned in the publication, the impact and relevance of the results, clinical translatability, as well as scientific quality of the journal. The nominated research groups will be rewarded to encourage the great work done.