Modulight Illumination Kit – Precision Laser Light for In Vitro & In Vivo Research

Tailorable and uniform laser illumination for frug screening, photosensitive samples, and biomedical research.

Controlled Illumination for Preclinical Studies

The Modulight Illumination Kit (MLAKIT) is designed for precise, uniform, and tailorable light delivery in in vivo and in vitro applications. Compatible with Modulight 6000 and 7000 series lasers, the kit ensures seamless integration with multi-wavelength and multi-channel laser sources, making it ideal for photosensitive samples, drug screening, and biomedical research.

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Application of Modulight Illumination Kits in Research

In Vitro Illumination

In vitro research often requires evenly distributed illumination over well plates, petri dishes, or other sample containers. Ensuring uniform light exposure is crucial to maintaining consistency across samples and obtaining reproducible results. Modulight’s Illumination Kit for in vitro applications is specifically designed to meet these requirements, incorporating a custom-built illumination chamber that facilitates easy attachment of laser sources, such as the ML6600.

The system’s precision-engineered optics provide high irradiance and uniform lighting, effectively eliminating intensity variations across the sample area. This ensures that all samples receive the same amount of light energy, a critical factor in experiments involving cell cultures, drug response testing, and microbiological research. By minimizing variations in light distribution, researchers can obtain more accurate and repeatable experimental outcomes.

In Vivo Illumination

For researchers conducting in vivo studies, precise light delivery to tissue samples is essential. Unlike in vitro applications, where light is evenly spread over a defined surface, in vivo illumination requires a more controlled approach, as tissue absorption and scattering can affect light penetration. Modulight’s Illumination Kit for In Vivo is specifically designed to address these challenges by providing superficial illumination.

The system consists of a sturdy, fixed setup where laser light from a source such as the ML6600 is directed through carefully designed optics. These optics create a circular illumination spot at a defined distance from the sample, ensuring that the light is delivered consistently at a fixed height. The ability to tailor the light spot diameter allows researchers to tailor the illumination area to different experimental needs, whether they are working with small localized tissue samples or larger exposed areas.

With its precisely controlled and adaptable design, Modulight’s Illumination Kit plays a key role in advancing preclinical phototherapy studies, ensuring researchers have the tools they need for highly reproducible and accurate experimental setups. Whether illuminating cell cultures in vitro or tissue samples in vivo, these kits provide an efficient and reliable solution for laser-based research.

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Key Benefits of the Illumination Kit

Different optical setups for both in vitro and in vivo use
Tailorable Spot Sizes for flexible in vivo illumination
For in vitro, different sample stations available: rectangular 85×125 mm multi-sample well plates, and up to 95 mm diameter round petri dishes
Seamless ML6600 Integration – Quick, secure connection via an SMA optical fiber.
Uniform Irradiance – Achieve higher and more even light distribution over large areas compared to DIY setups.
Advanced User Interface of the ML6600: intuitive, multi-channel graphical control system for easy irradiance adjustment, and built-in dose calculation for custom or discrete sample sizes.

Download MLAKIT Datasheet

Standard Illumination Characteristics

Optics	Irradiance Range (mW/cm²)
10 mm FWHM diameter	100–1000
20 mm FWHM diameter	40–400
30 mm FWHM diameter	20–180
70 mm FWHM diameter	4–30

Enhanced Performance with MLAKIT:

✔ Adjustable irradiance within a selected range

✔ Customizable optics for different experimental needs

✔ Supports multiple wavelengths for multi-wavelength laser illumination

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Prestigious Research Conducted with Modulight Illumination Kit

Laser-Sharp Research Award - University of Medicine and Pharmacy Carol Davila

ML6600 laser with MLAKIT was used to evaluate the effect of the compounds on cell viability, proliferation, and necrosis. One of the tested compounds showed superior qualities and high potential for further development as a promising dermatologic therapy.

Laser-Sharp Research Award - Leiden University & Aura Biosciences

This preclinical study combined immune checkpoint inhibitors with a light-activated virus-drug conjugate. As published in Cancer Immunology, Immunotherapy journal, the combination was effective against metastatic tumors and in most cases even resulted in complete responses to therapy.

Light-induced drug delivery with indocyanine green liposomes

Light-triggered drug release studies at University of Helsinki: ML6000 series laser system was used together with Modulight in vitro illumination kit to illuminate liposomes in plasma and in vitreous. Light-triggered release was studied and found that the liposomes were stable and the release was repeatable.

Get Started with The Modulight Illumination Kit!

Want to enhance your photoactivation and preclinical studies with precision-controlled laser illumination? Contact us today to discuss your application needs and find the optimal illumination setup for your research.