Protected: Fluorescence imaging & endoscopy for tumor visualization and diagnostics

There is no excerpt because this is a protected post.Introduction to fluorescence imaging Fluorescence is a phenomenon where substance that has absorbed certain wavelength of light emits it back at another wavelength. These substances are called fluorophores or fluorescent dyes. The emitted light has a longer wavelength than the absorbed one since some energy of the photon is lost in the process. The difference in wavelengths between absorbed and emitted light, called Stokes shift, allows very low background for fluorescence detection by separating it from the excitation light. The process of fluorescence generation is Continue reading →

Protected: In-vivo distribution and vascular & tumor responses

There is no excerpt because this is a protected post.Customer case Erasmus MC is the largest and one of the best University Medical Centers in Europe. Modulight products: ML7710 (689 nm) Laser use: Activation of antibody-IRDye700DX conjugates for photoimmunotherapy of cancer. Link to the study:   Dominic Robinson (PI)   Research Research centered on PDT encompasses 3 main themes: Understanding the mechanism of action/theoretical bases of PDT Developing technology for PDT dosimetry/treatment monitoring Receptor targeted PDT/PIT. Main indications of interest are dermatology, gastroenterology and H&N cancer. Most recently the group has investigated mechanisms & effectiveness Continue reading →

Protected: New approach for targeted PDT of glioblastoma

There is no excerpt because this is a protected post.Customer case Research in close collaboration with University Medical Center Utrecht, Erasmus Medical Center and Leiden University Medical Center. Research focused on the efficacy and mechanisms of targeted cancer photoimmunotherapy using nanobodies (antibody fragments). The advantage of nanobodies lies in the combination of their small molecular size, with high binding affinity for their targets, resulting to high accumulation at the tumor site, better tumor penetration and faster clearance from blood circulation. The aim is to target therapy to cancer cell-expressing antigens like EGFR (H&N cancer) Continue reading →