In vitro illumination using ML8500: osmium-based anticancer photosensitizer with highest hypoxic activity reported to date

  Study protocol to determine wavelength, fluence, and irradiance activities of Os-4T:   Key observations Illumination parameters significantly affected the phototoxicity of Os-4T. The green light (525 nm) was more effective than the red light (630 nm) at lower fluences, while the maximal potency was achieved at both wavelengths when using fluences higher than 100 J/cm2. Irradiance affected the potency with both the red and the green light that were more effective when lower irradiances were used.   Graphs from the original publication. Open-access content Continue reading →Basic Info of the Study Research by: University of Texas at Arlington, US. One of the leading groups in photoactive drug discovery. Developed first clinical-level rubidium-based PS (TLD-1433), now in Theralase-sponsored Phase 2 trials for bladder cancer. Modulight products: ML8500 (445 nm, 525 nm, 630 nm, 753 nm, 810 nm) Laser use: Photoactive drug discovery Link to the study: Dr. Sherri McFarland (see her referral of Modulight) Research topics: Medicinal inorganic chemistry and drug discovery. Special interest in the synthesis of novel transition metal complexes and Continue reading →

Fully automated illumination study series for modern cancer drug development

Fully automated illumination study series for modern cancer drug development In vitro cell viability and dose escalation study for developing photosensitive or photoactivated drugs using Modulight ML7710 medical laser and ML8500 automated illumination system.     Experimental set up        Fully automated illumination study series for modern cancer drug development In vitro cell viability and dose escalation study for developing photosensitive or photoactivated drugs using Modulight ML7710 medical laser and ML8500 automated illumination system.   STUDY PLAN The goal was to investigate the effect of irradiance and light dose on a cancer cell line while keeping the photosensitive drug dosing constant. The well-by-well dose escalation plan was done in tabular format. TARGET Cancer cell line incubated at 37°C in acidic culture DRUG TYPE Photosensitive or Continue reading →

Range Finding

    Laser range finding applications set several requirements for the laser device. High output power is required at the same time in very short pulses of even picosecond range. However, the required power is defined by the distance and reflectivity of the target. High power can be achieved by constructing several emitter stacks or by increasing a single emitter dimensions. Light pulses up to 120-150 Watts can be generated using Modulight’s laser diodes at 905 nm wavelength range. Though comparably lower output power with Continue reading →Laser range finding: How it works? Pulsed laser range finder is based on measuring the difference in properties of the transmitted and back-reflected light from the target. The target changes the properties of the incident light and the back-reflected light is analyzed in the receiving equipment. Modulight manu­factures range-finding lasers for various market segments. The distance measurement techniques are required in determining the height, width, distance, volume or movement of the target.  Applications for the technique are laser radar speed measurements, traffic safety, laser profiling Continue reading →