Category: Application Note | Page 2

Fluorescence imaging & endoscopy for tumor visualization and diagnostics

Application Note / 5-ALA, bladder cancer, bronchoscopy, cystoscope, cystoscopy, endoscope, endoscopy, fluorescence, gastroscopy, ICG, imaging, indocyanine green, Lung cancer, ML7710, NIR endoscopy, oncology, RGB / July 6, 2022

Several fluorescent agents have been approved for fluorescence based diagnosis & intraoperative imaging: Dye generic name Countries Excitation Detection Indications Indocyanine Green (ICG) Worldwide 800 nm Near-infrared (820 nm) Multiple uses: lymphatic mapping, tissue perfusion, visualization of biliary ducts and blood veins, retinal angiography Fluorescein Worldwide 490 nm Green fluorescence (525 nm) Fluorescein angiography or […]

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Flow cytometry

Application Note / 405nm, 488nm, 532nm, 561nm, 633nm, 640nm, 660nm, 808nm, cell sorting, diagnostics, flow cytometry, fluorescence, ML6600, research / March 28, 2022

Introduction Flow cytometry is a widely used method in biomedical research and increasingly also in clinical diagnostics. It is a powerful and rapid technique to analyze physical and chemical properties of single cells or particles as they are suspended in liquid and pass in a narrow line across laser beams. Fluorescence together with scattered laser

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Light-based enhancement of vaccination in humans

Application Note / 652 nm, bile duct cancer, HPV16, human papilloma virus, ML7710, PCI, PCI Biotech, T-cell response, vaccination, vaccine / December 20, 2021

Motivation Vaccines should activate all branches of immunity, including T cells and antibody responses, for generating a strong immune response. For therapeutic cancer vaccines, it is especially important to induce strong cytotoxic T-cell responses, since cytotoxic T-cells are the most potent immune cells for killing cancer cells. While cytotoxic T-cells can often be induced

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Optimizing photosensitizer administration for cancer therapy

Application Note / 630 nm, 631 nm, 665 nm, antimicrobial, drug distribution, intratumoral, ML7710, PDT, photofrin, University of Rochester / December 11, 2021

Customer case University of Rochester belongs among the nation’s top research universities. Research at the Baran lab focuses on anti-microbial PDT and optical image processing. The aim is to develop methods for utilizing quantitative information from CT, MR and PET imaging for PDT treatment planning as well as in the search of new biomarkers and

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Optimized light delivery in pancreatic cancer

Application Note / 689 nm, in vivo, interstitial, ML7710, pancreas, pancreatic cancer, phototherapy, tumor, University of California at Irvine / November 10, 2021

Customer case University of California at Irvine (UCI), founded in 1965, is a Top 10 public university in USA. It is recognized for cutting-edge and innovative scientific research. Modulight products: ML7710 (689 nm) Laser use: Targeted phototherapy studies with photo-immunoconjugates Link to the study: Nzola De Magalhães, Adjunct Assistant Professor Motivation for the study Efficient

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Light penetration depth in brain with different photosensitizers

Application Note / 5-ALA, 635 nm, 689 nm, BPD, brain cancer, glioblastoma, ML6600, PDT, Photoimmunotherapy, PIT, PPIX, University of Maryland, verteporfin / October 28, 2021

Motivation for the study Glioblastoma is the most aggressive and lethal brain cancer with an average prognosis of 15 months. Fluorescence-guided surgery (FGS) for glioblastoma was FDA-approved in 2017, while photodynamic therapy (PDT) remains an active area of clinical investigation with very promising results so far. The aim of PDT is to eradicate the

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Multimodal imaging microscope for tissue engineering applications

Application Note / 488nm, 561nm, 638nm, imaging, in vitro, microscopy, ML6600, multimodal imaging, OPT, RGB, SPIM, stem cells / September 14, 2021

Motivation for the study Tissue engineering is an evolving field of medicine that aims to grow new viable tissue for repairing or regenerating damaged tissues in the body. These tissue constructs are typically made by placing cells in support matrices that have proper growth-inducing factors. However, visualizing the development and composition of these tissue

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Light delivery optimization for H&N cancer treatment

Application Note / 630 nm, cancer, dosimetry, H&N cancer, head & neck cancer, in vivo, iPDT, ML6500, ML7710, oncology, PDT, Roswell Park / August 30, 2021

Results Illumination with one fiber Some level of tissue heating was observed at all used light intensities. At lower intensities (60-100 mW/cm), less than 5% of the tumor was subjected to >60 ⁰C temperature, a point where irreversible thermal damage will immediately occur (photothermal ablation). At intensities of 150-200 mW/cm, 15-20% of the tumor was

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Antimicrobial PDT for prosthetic joint infections

Application Note / anti-infection, antimicrobial, in vitro, methylene blue, MRSA, prosthetics, Royal National Orthopaedic Hospital, UCL / August 21, 2021

Motivation for the study Periprosthetic joint infections after hip and knee replacement surgeries are associated with high patient morbidity and a large financial cost. Challenging two-stage revision surgeries are required with long antibiotics regimes that can have limited efficacy and cannot eradicate drug-resistant strains like MRSA (methicillin-resistant Staphylococcus aureus). This study aims to investigate the

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