In Vitro and In Vivo illumination
Modulight provides a versatile and comprehensive product family for in-vitro and in-vivo illumination. Modulight lasers are used in many cell research laboratories worldwide to study photodynamic therapy (PDT). PDT utilizes photosensitizers that can be activated with specifically designed light sources – reactive oxygen is created at the target due to light activation.
Photosensitizers are also used in targeted drug delivery, and light activation is used for releasing the drug from the cargo. The PDT is on the verge of bringing another revolutionizing tool to be used in the treatment of glioblastoma, uveal melanoma, bile duct, pancreatic, and many other cancers.
Modulight’s in-vitro and in-vivo product family enables illumination of anything. We make lasers with variety of wavelengths, ranging from 400 to 2000 nm. Thus, we can support the research of all existing photosensitizers.
Our product offering: from In Vitro to Clinic with Modulight lasers
Products: ML8500, ML 6600, ML6500, Illumination Kit
Used for illuminating cells on well plates or petri dishes
Dose escalation studies (changing drug dose or light dose) etc. usually combined to cell viability assays
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Products: ML7710, ML6600, ML6500, Illumination Kit
Used for illuminating animal test subjects
Dose escalation studies (changing drug dose or light dose)
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Products: ML7710, ML7710i, ML6710i +SLA
Used in clinical trials and also at clinics for some applications
Oncology, ophthalmology
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Application Notes and Articles by Our Customers
Published in: Advanced NanoBioMed Research Authors: John A. Quinlan, Kaylin Baumiller, Anandita Gaur, Wen-An Chiou, Robert W. Robey, Michael M. Gottesman, Huang-Chiao Huang A nanosuspension of verteporfin, termed NanoVP, that requires no carriers is developed, permitting delivery of VP alone in an aqueous solution. NanoVP is produced by solvent–antisolvent precipitation, with dimethyl sulfoxide as the preferable solvent. The paper describes the characterization of NanoVP, including bioavailability and anticancer capacity in glioblastoma with ML6600 laser irradiation, as well as potontial of NanoVP for light-independent therapy. Read Continue reading →
Modulight Spotlights: LASER-SHARP RESEARCH – September 2024 University of Maryland and Modulight have published together a new research study about the mechanisms of cancer drug resistance. Drug resistance is a leading cause of treatment failure and often has dramatic consequences for survival of cancer patients. Cancer cells have developed various ways to protect themselves from drugs. When several clinically used photoactive drugs were studied, it was shown that some of them were being actively pumped out by cancer cells, thus likely limiting the full therapeutic potential Continue reading →
Published in: Cancer Drug Resistance Authors: Shruti Vig1, Payal Srivastava1,#, Idrisa Rahman1,2,#, Renee Jaranson1, Anika Dasgupta1, Robert Perttilä3, Petteri Uusimaa3, Huang-Chiao Huang1 University of Maryland and Modulight have published together a new research study about the mechanisms of cancer drug resistance. Drug resistance is a leading cause of treatment failure and often has dramatic consequences for survival of cancer patients. Cancer cells have developed various ways to protect themselves from drugs. When several clinically used photoactive drugs were studied, it was shown that some of them were being actively pumped out by cancer cells, thus likely limiting the full therapeutic potential of these Continue reading →
Watch video about Modulight's In Vitro / In Vivo Solutions
Essential products for in vivo, in vitro, and preclinical applications
ML8500 – automated biomedical illumination device – provides targeted illumination for microplates. Each well is automatically and sequentially illuminated with a specific dose, irradiance and wavelength. Environmental parameters, like carbon dioxide content and temperature, can be adjusted. Optional fluorescence monitoring and cell imaging are also available. ML8500 supports various microplates (24/96/384/1536) and petri dishes. Illumination programs can be created remotely, and collecting data from the cloud can be conveniently done from the office – no need to control the illumination at the lab. Cloud connection enables also the remote support, service, and upgrades.
ML7710 is the most versatile oncology laser system for PDT studies, and the same product can be used for in-vitro/vivo studies and clinical therapies (CE mark, FDA approval for some combination therapies). The ML7710 is a cost-effective solution for long-term study plan including pre-clinical and clinical phases – using the same device from first phase studies to clinical tests makes regulatory work faster. The ML7710 is used already in many clinics and in well-known cancer centers worldwide. We provide internet connectivity, remote diagnostics, cloud services, and low-cost upgrades.
Modulight Illumination Kit is a series of accessories that enable uniform, parallel illumination of petri dishes and well plates. The whole sample plate is illuminated simultaneously in a specially designed illumination chamber. The laser light source can be an ML7710, or very compact but powerful ML6500 and ML6600 laser modules. ML6500 enables the use of one wavelength and ML6600 up to 3 wavelengths. These laser sources can be used together with different light delivery options, e.g., SMA connected fiber with a frontal diffuser at the end. Most popular option among in vitro studies is to have our Illumination Kit sample stage that enables illumination of the well plate.
Modulight provides also many different and customized sample stage designs which can be tailored to fit any illumination target. We provide support for dose calculation and calibration, and our lasers have simple graphical user interfaces or they can be controlled from the computer. Products are supported with full suite of services from calibration to on-site training.
Illumination solution can be customized to your needs:
- Wavelength can be selected between 400 – 2000 nm
- Irradiance and dose can be adjusted
- Different sample stages supporting the use of microplates, petri dishes, and possibility for customized
- Handpiece enables in vivo subcutaneous illumination, option for spot size adjustment
- We provide many different medical fiber options
- Controlled and repeatable illumination, support for dose calculation
- Possibility to use 1-8 different wavelengths
- Pulsing possible in ms – µs range
- On-site training
- Regular calibrations and device support
In-vitro and in-vivo customer referrals
Poul Martin Bendix, PhD, Associate Professor at Niels Bohr Institute
Sherri McFarland, PhD, Professor at University of Texas at Arlington (Formerly Professor at The University of North Carolina at Greensboro)
